Title



     mr -- Mendelian randomization programs



Syntax



        mr subcommand ... [aweight] [if] [in] [, options]



Description



    mr is a simple wrapper to the commands in the mrrobust package.



    The subcommand is specified as the mrrobust program name without its mr prefix, i.e. mregger
    ... can alternatively be run using the syntax mr egger ....



Options



    mr takes the options for the specified subcommand.



Examples



    Using the data provided by Do et al. (2013) recreate Bowden et al. (2016), Table 4, LDL-c "All
    genetic variants" estimates.



    Setup
        . use https://raw.github.com/remlapmot/mrrobust/master/dodata, clear



    Select observations (p-value with exposure < 10^-8)
        . gen byte sel1 = (ldlcp2 < 1e-8)



    IVW (with fixed effect standard errors)
        . mr egger chdbeta ldlcbeta [aw=1/(chdse^2)] if sel1==1, ivw fe



    Scatter plot of MR-Egger model
        . mr eggerplot chdbeta chdse ldlcbeta ldlcse if sel1==1



    Multivariable IVW
        . mr mvivw chdbeta ldlcbeta hdlcbeta tgbeta [aw=1/(chdse^2)] if sel1==1



Stored results



    mr returns the results from the specified subcommand.






References



    Bowden J, Davey Smith G, Haycock PC, Burgess S. Consistent estimation in Mendelian
        randomization with some invalid instruments using a weighted median estimator. Genetic
        Epidemiology, 2016, 40, 4, 304-314.  DOI



    Do et al., 2013. Common variants associated with plasma triglycerides and risk for coronary
        artery disease. Nature Genetics. 45, 1345-1352.  DOI



Author



INCLUDE help mrrobust-author